Projects:

• Development of Sensors and Inhibitors for protein aggregates [2017 - 2020]

        Protein misfolding and agglomeration is a hallmark of many amyloid diseases. In case of many diseases ranging from Alzheimer’s, Parkinson’s, Creutzfeldt Jakobs to something as common as Diabetes and those caused by Prions, the active protein loses its functional conformation and transforms into the inactive state. This conversion of a protein from its active alpha helix form to inactive Beta sheet deems the protein ineffective and their accumulation leads to the progression of the disease. In an attempt to detect these beta sheet of various proteins we have developed sensors which offer sensitivity and selectivity to protein aggregates.

• Evaluation of Fluorescent Sensors for detection of Alzheimer’s protein and testing of Inhibitors for Anti-Alzheimer’s activity [2020 - Current]

       Many amyloid diseases are neurodegenerative and terminal and affect large populations of elderly, for instance, Alzheimer's disease and Parkinson's disease which are the major contributors to dementia. As per WHO, the global estimation for the prevalence of dementia is 50 million people (as of 2019) out of which 60-70% of the cases are attributed to Alzheimer’s Disease. This necessitates the development of better sensors for detection in early stages and inhibitors with high efficiency. We have developed near-infrared sensors which can effectively detect β amyloid in early stages.

Achievements:

• Research paper publications in high impact factor International Journals
• Review paper
• M.Sc. Thesis Publication
• Patents
• Cell Toxicity Studies
• Efficacy and Toxicity study in Animal Models

Project Training:

We invite applications from the eligible candidates who are interested in pursuing research in biological and biophysical sciences, having one of the following qualifications to undertake 4 to 6 months project training as a part of their dissertation work / course curriculum.

• Students in their final year of B.Sc, B.Pharm.
• Students in their final year of M.Sc, M.Pharm, Integrated M.Sc.

Internship:

We provide internship opportunities to undergraduates and postgraduates in Biological and chemical sciences. We have an intake of 4 interns per year. Students are welcome to join us for some amazing research work along with a chance to get your research published.

Patents:

Selected Publications:

1. Kamat D.V and Muthe P.T. Poisonous Effects of E. tirucalli on Fish. J. Anim. Morpho. Physiol.    42(1&2): 65. 1995. ISSN 0021-8804.
2. Kamat D.V. and Muthe P.T. Study on Antimicrobial Activity of Calendula officinalis. Quinquina, pp.25. 1995.
3. Kamat D.V and Chakraborty B.P. Comparative Values of CSF- Cholesterol and CSF- Triglycerides along with other Biological Parameters in Neurological Disorders. Ind. J. Med. Sciences.  42(8): 280. 1996. ISSN 0018-5359.
4. Pal. B, Sharon M., and Kamat D. V. Photo catalytic Bactericidal Action of Commercial Grade Fe₂O₃ Powders on Pathogenic Bacteria. Chem. and Environ. Res. 5(1-4): 51. 1996. ISSN 0971-2151.
5. Kamat D. V. Thomas M, Bhagwat A. M. and Muthe P.T. Inhibition of Carbonic Anhydrase by Extract of E. tirucalli and E. antiquorum in Fish and Prawns. J. Anim. Morpho. Physio.  44(2): 155. 1997. ISSN 0021-8804.
6. Kamat D. V. and Chakraborty B.P. Comparative Values of CSF-LDH Isoenzymes in Neurological Disorders. Ind. J. Med. Sci. 53(1) : 1. 1999. ISSN 0018-5359.
7. Revankar S.N, Desai N.D, Bhatt A.D, Bolar H.V, sane S.P. Gupta C. and Kamat D.V. Comparative Bioequivalence of Carbamezapine Availability. JAPI, 1999. ISSN 0004-5772
8. Kamat D.V, Kamat S.D and Bandekar P.P. Activity of Couroupita guianensis against organisms causing superficial skin infections. J. Micro. world. 6(2): 113.2004. ISSN 2008-3068.
9. Sharon M., Pal B. and Kamat D.V. Photo catalytic killing of pathogenic bacterial cells using nano size Fe₂O₃ and carbon nano tubes. J. Of Biomedical Nano technology. 1: 365-368. 2005. ISSN 1550-7033.
10. Kamat S.D, Kamat D.V. and A. Mathew. Study of Emergence of Drug Resistance in Enterobacteriaceae spp. J. Microbial world. 9(2): 195-200. 2007. ISSN 2008-3068.
11. Joshi M, Kamat D.V. and Kamat S.D. Evaluation of Herbal Hand wash Formulation. Natural Product Radiance 7(5):413.2008. ISSN 0976-0504.
12. Panvalkar S.S., Kamat S.D and Kamat D.V. Phyto-remediation and Bioremediation of Textile Effluent. Proceedings of National Conference of Emerging Fields in Life Sciences. 2009.
13. R. Amudan, R. Thomas, Kamat D.V and Kamat S.D. Quantification of Phytochemicals of Terminalia chebula fruit extracted using physical and biological methods. Proceedings of National Conference on Emerging Fields in Life Sciences. 2009.
14. R. Amudan, Parchure D., Kamat D.V. and Kamat S.D. Extraction of Phytochemicals with the use of Microbial Enzymes. Bionano frontier. 3(1): 18-20. 2010. ISSN 0974-0678.
15. S. Deepak, Kamat S.D., and Kamat D.V. Effect of Aqueous Extract of Terminalia chebula on Metallo-betalactamase. Int. J. Pharmacy &. Pharmaceut. Sci. 2(4): 172. 2010. ISSN 1976-3786.
16. S. Deepak, Kamat S.D. and Kamat D.V. Incidences of presence of Multiple beta-lactamases in Pseudomonas and Acinetobacter isolates. Asian J. Biochemical . And Pharmaceutical. Res.  3(1): 332. 2011. ISSN 2231-2560
17. Desai J.V., Thomas R., Kamat S.D. and Kamat D.V. Microwave assisted extraction of saponins from Centella asiatica and its in vitro anti-inflammatory activity. Asian J. Biochemical and Pharmaceutical Res. 1(4):345. 2011. ISSN 2231-2560.
18. R. Amudan, Kamat D.V. and Kamat S.D. Enzyme Assisted Extraction of Essential Oil from Syzium aromaticum. South Asian J. Exp. Biol. 1(6): 248, 2011. ISSN 2230-9799
19. Rabadia A, Kamat S.D and Kamat D.V. Antifungal activity of Essential Oils against Fluconazole resistant Fungi. Int. Jou. Phyto Medicine. Vol. 3: 506-510. 2011. ISSN 0975-0185.
20. Thomas R., Tripathi R., Kamat S.D. and Kamat D.V. Comparative Study of Phenolics and Anti- oxidant activity of T. chebula extracted using microwave and Ultra sonication. Int. J. Pharmaceutical. Sci. & Res. 3(1) 194. 2012. ISSN 0975-8232.
21. Panvalkar S., Kamat S.D., Kamat D.V. Comparative Study of Physico-chemical and Biological Treatment of Textile Industry Effluent. Bionano Frontier Vol. 5(1): 34-36. Jan- June 2012. ISSN 0974-0678
22. Aroskar V., Kamat S.D., and Kamat D.V. Effect of various nutritional supplements on Hyaluronic acid production. IIOAB Letters. 2012. ISSN 2161-3702
23. Aroskar V, Kamat S.D. and Kamat D.V. Effects of Various Physical Parameters and Statistical medium optimization on production of Hyaluronic acid using S. aqui sub spp zooepidermicus ATCC 39290. IIOAB Letters. 2012. ISSN 2161-3702
24. Desai J.V., Thomas R., Kamat S.D and Kamat D.V. Comparative studies on in vitro anti-inflammatory activity of Andrographis paniculata and Baccopa monerii. J. Adv. Pharma. Res. Vol. 2: 5 – 8. 2012. ISSN 2229-3787
25. Rabadia A., Kamat S.D and Kamat D.V. Study of Synergistic action of Cifotaxime and T. chebula on Acenetobacter baumannii using checker board assay. Int. J. Pharmacy and Pharma. Sciences. Vol. 5 (3). 830 – 832. 2013. ISSN 0975-1491
26. Kohmaria R., Kamat S.D. and Kamat D.V. Study of Microbicidal Action of Vapors of Essential Oil of Trachyspermum ammi. Bionano Forntier Vol. 6 (3): 129 – 130. 2013. ISSN 0974-0678
27. Balsubramanian A., Kamat S.D and Kamat D.V.  Formulation of Nutmeg Oil Micro emulsion and its Antimicrobial Activity against Streptococcus mutans. Bionano Forntier Vol. 6 (3): 104 – 106. 2013. ISSN 0974-0678
28. Harmalkar A., Shaikh M, Kamat S.D and Kamat D.V. Enzyme Assisted Transformation of Glycosides. South Asian Jou. Of Biolo. Sci. 3(2) : 40 -45. 2013. ISSN 0249-6599
29. Rabadia A., Kamat S.D and Kamat D.V. Studies on Effect of Cefotaxime and Terminalia chebula on E. coli. Int. Jou. Pharma. Bio. Sci. 4(4B): 519-523. 2013. ISSN 0975-6299
30. Joshi M., Kamat S.D. and Kamat D.V. Fungal Pigment: Characterization and Applications. BIONANO FRONTIER, 7(1): 34-40. 2014. ISSN 0974-0678
31. Shaikh M, Ullal A., Kamat S.D. and Kamat D.V. Aspergillus niger assisted transformation of Alkaloids. BIONANO FRONTIERS, 7(1): 46- 48. 2014. ISSN 0974-0678
32. Thomas R., Kamat S.D. and Kamat D.V. Microwave and Ultra sonication assisted extraction of phytochemicals from B. monnieri and study of its anti-oxidant activity. Int. J. Of Pharma and Biosciences.2014. Jan 5(1): 66-69. ISSN 0975-6299
33. Joshi M, Kamat S.D and Kamat D.V. Fungal Pigment: Characterization and Applications. BIONANO FRONTIER, 7(1): 34-40. 2014. ISSN 0974-0678
34. Shah P, Shah S, Kamat S.D and Kamat D.V. Colistin Carbapenem combination therapy against carbapenam resistant gram negative bacilli infections; Clinical and an in vitro synergy study. IJPPS Vol. 6(10) :497-500. 2014. ISSN 0975-1491
35. Yoosuf S, Kamat S.D. and Kamat D. V.  Evaluation of Antifungal effect of Coriander oil based Nano emulsion. Proceeding of UGC sponsored Two Day national seminar on Fungi in Biotechnology. 28 – 29 November 2014. S.I.E.S college of Arts and Science, Mumbai. ISBN 978-81-920431-9-7
36. Yoosuf S, Kamat S.D and Kamat D.V. A comparative antifungal study Of Coriander oil and its Nano emulsion. Life Sciences International Journal Vol. 2: 69-74 2015. Special issue with CHM College. ISSN 2347-8691
37. Pawar J, Kamat D.V and Kamat S.D.  A comparative study of ozonated and non ozonated effluents to screen novel paranitrophenol degraders. Life Sciences International Journal Vol. 2 pp 83-88 2015. Special issue with CHM College. ISSN 2347-8691
38. Shah P, Anusha B, Shah S, Kamat S.D and Kamat D.V  Comparative evaluation of an in-house and commercially available medium for detecting carbapenem resistant Gram negative bacilli in surveillance rectal swab and identification of predisposing risk factors for colonization. Int.  J. of Pharma and Biosciences. 2015 April. 6(2) (B): 641-646. ISSN 0975-6299
39. Thomas R., Kamat S. D and Kamat D.V. HPTLC and HPLC analysis of T chebula extracts prepared using microwave and ultra sonication assisted extraction methods.  Journal of Pharmacognosy and Phytochemistry. 2015 4(1); 192-196. ISSN 2278-4136
40. Thomas R, Kamat S.D and Kamat D.V. Comparative study of antiplatelet aggregation activity of B. monnieri extracted using microwave and ultra sonication. Int. J. of Advances in Pharmacy, Biology and Chemistry. 2015. 4(2) Apr-Jun 409-413. ISSN 2277-4688
41. Pooja Shah P.,  Shah S, Kamat S.D and Kamat D.V  Epidemiology Clinical Characteristics and outcomes of Carbapenen resistant Enterobectericae infection in a tertiary care hospital. Int. J. Innovative Pharmaceutical Sci. Res. 3(4): 267-277. 2015. ISSN 2347-2154
42. Kamat D. V. and Kamat S. D. Bioremediation of industrial effluent containing reactive dyes. Int. J. of Env. Sc. 5(6): 1078-1084. 2015. ISSN 0976-4402
43. Yoosuf S, Kamat S.D. and Kamat D.V. Checkerboard assay to assess synergistic action of Fluconazole and essential oils of Ajwain and Coriander against Candida spp.    Int. J. of  Pharma and Biosciences. 2016. ISSN 0975-6299
44. Ritweek Sureka, Shivangi Joshi, S. D. Kamat and D. V. Kamat. Bio sorption of metal Ions to reduce load on reverse osmosis systems. IOSR Journal of Environmental Science, Toxicology and Food Technology. Vol. 10(4) 28-31. 2016. ISSN 2319-2399
45. Shah P.G., Shah S.R., Kamat S.D., Kamat D.V. Characterization Of Carbapenem Resistant Acinetobacter baumannii Isolated in a Tertiary Care Hospital. Int. Jou. of Pharmacy and Pharmaceutical Sciences. 8(7):277-281. 2016. ISSN 0975-1491.
46. NirmlaDevi Thakur, Nancy S. Pandita Pharmacognostic screening, phytochemical evaluation and synthesis of silver nanoparticles using leaves of Mimusops elengi Linn. PHARMANEST- An International Journal of Advances in Pharmaceutical Sciences. 2015; 6(4): 2870-2873
47. Thakur N, Pandita N; et al. Pharmacognostic and phytochemical investigation of Juglans regia Linn. Bark. Pharmacognosy Journal, 2011; 3(25): 39-43.
48. Apraj V, Thakur N, Pandita N, et al. Pharmacognostic and  phytochemical evaluation of Citrus aurantifolia (Christm) Swingle Peel. Pharmacognosy Journal, 2011; 3(26): 70-76.
49. Sanganeria P, Chandra S, Bahadur D, Khanna A. (2015).Effect of HSA coated iron oxide labeling on human umbilical cord derived mesenchymal stem cells. Nanotechnology. 2015 Mar 27;26(12):125103
50. Purva Sanganeria, Shilpee Sachar, Sudeshna Chandra, Dhirendra Bahadur and Aparna Khanna (2015). Cellular Internalization and Detailed Toxicity Analysis of Protein Immobilized Iron Oxide Nanoparticles J Biomed Mater Res B Appl Biomater. 2015 Jan;103(1):125-34.
51. Agrawal V, Bhagwat AM, Vishalakshi V, Gode V, Sawant CS. Exploring the potential of chromogenic medium for the identification of medically important yeast species other than Candida. International Journal of Pharmacy and Pharmaceutical Sciences. 2014. 6(3): 291-294.
52. Agrawal V, Bhagwat AM, Sawant CS. Sesame oil incorporated medium for isolation and enumeration of lipophilic yeasts. International Journal of Pharmaceutical Sciences and Research. 2014. 5(7): 2971-2979.
53. Agrawal V, Bhagwat AM, Vishalakshi V, Sawant CS. An exploratory study to ascertain the aerobic cocci present on dandruff afflicted human scalps. International Journal of Life Sciences. A(1): 123-126.
54. Mehta R, Jholapara R, Sawant C. Isolation of a novel feather degrading bacterium and optimization of cultural conditions. International Journal of Pharmacy and Pharmaceutical Sciences. 2014. 6(1): 194-201.
55. Jholapara R, Mehta R, Sawant C. Optimization of cultural conditions for chitinase production from chitinolytic bacterium isolated from soil sample. International Journal of Pharma and BioSciences. 2013. 4(2): 464-4
56. Jholapara RJ, Mehta RS, Bhagwat AM, Sawant CS. Exploring and optimizing the potential of chitinase production by isolated Bacillus spp. International Journal of Pharmacy and Pharmaceutical Sciences. 2013. 5(S4): 412-418.
57. John NR, Gala VC, Bhagwat AM, Sawant CS. HPTLC analysis of Eclipta prostrata and Psidium guajava extracts and their effect on cell-surface hydrophobicity of a consortium of dental plaque isolates. International Journal of Pharmacy and Pharmaceutical Sciences. 2013. 5 (S3): 935-940.
58. John, NR, Gala, VC, Sawant CS. Inhibitory effects of plant extracts on multi- species dental biofilm formation in vitro. International Journal of Pharma and BioSciences. 2013 4(2): 487-495.
59. Mehta R, Bhagwat A, Sawant C. Antimicrobial potential of methanolic extracts of leaves of Epipremnum aureum (Linden & Andre) G. S. Bunting. Internation Journal of Pharmacy and Pharmaceutical Science. 2013. 5 (3): 918-922.
60. Mehta RH, Bhagwat A, Karmarkar S, Sawant C. A pharmacognostic and preliminary phytochemical study of Epipremnum aureum (Linden & Andre) G. S. Bunting. International Journal of Phytomedicine. 2013. 5 (2): 217-227.
61. Mehta R, Jholapara R, Sawant C. Optimization of cultural conditions for extra cellular keratinase production by Bacillus species isolated from poultry farm soil. International Journal of Pharma and Bio Sciences. 2013. 4(2): 454- 463.
62. Satish Totey and Aparna Khanna. Stem Cell Research in India – An Update. Genetics Policy Institute: World Stem Cell Report (Oct 2010)
63. Koka PS, Khanna A. Foreword: A compendium on latest developments in stem cell research and cell therapy applications (2009). Journal of Stem Cells 4(2):81-3.
64. A. Khanna, S. Shin, M.S. Rao. Stem cells for the treatment of neurological disorders. 2008; CNS Neurol Disord DrugTargets 7(1): 98-109 (Invited review).
65. R. Pal, S. Shaikh and A. Khanna. Generation and transplantation of human embryonic stem cell (hESC)- derived cardiomyocytes in mouse model of non-ischemic cardiomyopathy. 2008; J Stem Cells 3(3).
66. Mehta A, Konala VB, Khanna A, Majumdar AS. (2008).Assessment of drug induced developmental toxicity using human embryonic stem cells. Cell Biol Int. 2008 Nov; 32(11):1412-24 .
67. R. Pal, A. Mehta and A. Khanna. Cell cycle regulation in maintaining immortality of embryonic stem cells. 2007; J Stem Cells 2(3): 159-166.
68. R. Pal and A. Khanna. Heart development: the battle between mesoderm and endoderm. 2007; Stem Cells Dev 16(1): 3-5 (Invited review).
69. R. Pal, A. Mandal, H.S. Rao, M.S. Rao and A. Khanna. A set of tests to standardize characterization of human embryonic stem cells. 2007; Regen Med 2(2): 179-192.
70. A. Khanna, A.M. Swistowska, M.S. Rao, X. Zeng. Generation and transplantation of dopaminergic neurons derived from embryonic stem cells. 2006; Current Stem Cell Res Ther 2: 139-147 .
71. R. Pal and A. Khanna. Similar pattern in cardiac differentiation of human embryonic stem cell lines, BG01V and ReliCell®hES1 under low serum concentration supplemented with BMP-2. 2007; Differentiation 75(2): 112-122.
72. M. Bibikova, E. Chudin, B. Wu, L. Zhou, E. Wickham Garcia, Y. Liu, S. Shin, T.W. Plaia, J.M. Auerbach, D.E. Arking, R. Gonzalez, J. Crook, B. Davidson, T.C. Schulz, A. Robins, A. Khanna, P. Sartipy, J. Hyllner, P. Vanguri, S. Savant-Bhonsale, A.K. Smith, A. Chakravarti, A. Maitra, M. Rao, D.L. Barker, J.F. Loring, Jian-Bing Fan. Human embryonic stem cells have a unique epigenetic signature. 2006; Genome Res 16(9): 1075-83.
73. A. Mandal, S. Tipnis, R. Pal, G. Ravindran, B. Bose, A. Patki, M. S. Rao and A. Khanna. Characterization and in vitro differentiation potential of a new human embryonic stem cell line, ReliCell®hES1. 2006; Differentiation 74(2-3): 83-91.
74. J. Kulkarni and A. Khanna. Functional hepatocyte-like cells derived from mouse embryonic stem cells: A novel in vitro hepatotoxicity model for drug screening. 2006; Toxicology In Vitro 20: 1014-1022.
75. R. Pal and A. Khanna. Role of Smad and Wnt - Dependent pathways in Embryonic Cardiac Development. 2005; Stem Cells Dev 15(1): 129-139.
76. R. Pal and A. Khanna. Role of hepatocyte-like cells in differentiation of cardiomyocytes from mouse embryonic stem cells. 2005; Stem Cells Dev 14(2): 153-161.
77. S. Kashyap, R. Pal, A. Khanna, S. Tipnis, G. Ravindran and F. Khan. The transdifferentiation potential of limbal fibroblast-like cells. 2005; Dev Brain Res; 160: 239-251.
78. Aparna Khanna and Ranjit Ray. Hepatitis C virus core protein synthesis, affinity purification and immunoreactivity with infected human sera. 1995; Gene 153:185-189.
79. Ranjit Ray, Aparna Khanna, Keith Meyer, Q-L Choo, Robert Ralston, M. Houghton and Paul Becherer. Peptide Immunogen mimicry of putative E1 glycoprotein specific epitopes in hepatitis C virus. 1994; Journal of Virology 68: 4420-4426.